1. IMMUNOLOGY

A. Food and Inhalant Allergy Estimates of the proportion of the population allergic to foods vary around 50% and this figure has increased over the last 50 years. An increase in the variety of foods eaten as well as increased early exposure to cow's milk formula have both contributed to the rise in food allergies.

Symptoms vary widely. The immediate, obvious IgE-mediated food reactions include hives, wheezing, rhinorrhea, vomiting and anaphylaxis. Delayed or IgG-mediated reactions include non-obvious, chronic symptoms such as headache, digestive complaints, musculoskeletal symptoms and skin disorders such as eczema and psoriasis.

Prominent allergist J.C. Breneman, M.D. once wrote, "food allergy is often overlooked . any patient with confusing, prolonged complaints or poor treatment response might recover amazingly on a week of diagnostic elimination diet."

Consideration of food allergy is a critical component of any comprehensive approach to good health and for prevention of illness, and an elimination diet approach remains the gold standard for diagnosis of food allergy.

Meridian Valley Laboratory uses a state of the art enzyme-linked immunosorbent assay technique (ELISA, 96-well format for best precision) to measure serum antibodies to foods Panel Of Tests "E Panel: basic foods including 95 commonly eaten foods.

Panel Of Tests

"E Panel: basic foods including 95 commonly eaten foods.

"A Panel: an additional 95 common foods and seasonings, with no overlap of the E Panel.

"Inhalants are region-specific, including panels of common tree, grass, weed, and mold from each region of the US (NW, SW, W, NE, SE).

"All inhalant panels include cat, dog, mite (environmental) antigens, and molds.

"Both IgE and IgG4 antibodies are measured for foods; IgE is tested for inhalants. Common Indications

"Depression

"Aphthous stomatitis

"Asthma "Eczema

"Attention deficit disorder with hyperactivity "Autism

"Chronic fatigue syndrome

"Dermatitis herpetiformis

"Epilepsy "Gallstones

"Inflammatory bowel disease - ulcerative colitis, Crohn's disease

"Intestinal dysbiosis, Candidiasis

"Intestinal hyperpermeability "Irritable bowel syndrome

"Migraine headache

"Multiple sclerosis

"Otitis media "Peptic ulcer

"Psoriasis

"Rosacea "

"Seborrheic dermatitis"

"Urticaria"

B. CELIAC PROFILE

Anti-Endomysial IgA And Anti-Gliadin IgA And tTG

100% Specific for Celiac Disease

95% Sensitive for Celiac Disease

QuANTA Lite tTG (Tissue Transglutaminase) ELISA

For In Vitro Diagnostic Use

Celiac disease and dermatitis herpetiformis, the two recognized forms of gluten sensitive enteropathy (GSE) are characterized by chronic inflammation of the intestinal mucosa and flattening of the epithelium, or positive "villous atrophy". Intolerance to gluten, the protein of wheat, rye and barley, causes GSE. Patients with celiac disease may suffer from diarrhea, or other problems, anemia, fatigue, psychiatric problems and other diverse side effects or they may be asymptomatic. Dermatitis herpetiformis is a skin disease associated with GSE. All GSE patients have an increased risk of Lymphoma. A gluten-free diet controls GSE and associated risks.